tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

Base Information

Chemical Name:tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate
CAS No.:1537881-21-2
Molecular Formula:C₃₀H₃₆F₃N₅O₃S
Molecular Weight:603.709
Hs Code.:

tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

Synonyms:tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

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Chemical Property of tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

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Technology Process of tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

There total 6 articles about tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1537879-91-6
tert-butyl ((3aR,5R,6aR)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

: 622-78-6
Benzyl isothiocyanate

: 1537881-21-2
tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1443232-24-3
methyl (3aR,5R,6aR)-2-benzyl-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylate

: 1537881-21-2
tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: 5% Pd(OH)2/C; hydrogen / methanol / 2585.81 Torr

2: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3: potassium hydroxide; water / tetrahydrofuran / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 20 °C

5: hydrogen; palladium 10% on activated carbon / methanol / 1292.9 Torr / Inert atmosphere

6: tetrahydrofuran / 1 h / 20 °C

With 5% Pd(OH)2/C; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1537880-03-7
(3aR,5R,6aR)-2-((benzyloxy)carbonyl)-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylic acid

: 1537881-21-2
tert-butyl ((3aR,5R,6aR)-2-(benzylcarbamothioyl)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)octahydrocyclopenta[c]pyrrol-5-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / tetrahydrofuran / 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 1292.9 Torr / Inert atmosphere

3: tetrahydrofuran / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol;