N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Base Information

Chemical Name:N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide
CAS No.:1380662-89-4
Molecular Formula:C₂₆H₃₂FN₅O₆
Molecular Weight:529.568
Hs Code.:

N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Synonyms:N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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Chemical Property of N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

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Technology Process of N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

There total 5 articles about N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380665-23-5
N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-7-(1-hydroxyethyl)-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N₁,N₁-dimethyl-ethanediamide

: 1380662-89-4
N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: With lithium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

Reference yield:

: 1380665-18-8
N-[7-[(acetyloxy)methyl]-2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-carbamic acid phenylmethyl ester

: 1380662-89-4
N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / methanol

2: 4-methyl-morpholine; HATU / 1 h

3: sodium carbonate / acetonitrile; water; methanol / 1 h

4: Dess-Martin periodane / dichloromethane

5: toluene; tetrahydrofuran / 2.17 h

6: lithium chloride / N,N-dimethyl-formamide / 1 h / 120 °C

With 4-methyl-morpholine; hydrogen; sodium carbonate; Dess-Martin periodane; HATU; lithium chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1380665-22-4
N-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-7-formyl-6,7,8,9-tetrahydro-3-methoxy-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N',N'-dimethyl-ethanediamide

: 1380662-89-4
N'-[2-[[[(4-fluoro-3-methylphenyl)methyl]amino]carbonyl]-6,7,8,9-tetrahydro-3-hydroxy-7-(1-hydroxy ethyl)-4-oxo-7,10-ethanopyrimido[1,2-a]azepin-10(4H)-yl]-N,N-dimethyl-ethanediamide

Guidance literature:: Multi-step reaction with 2 steps

1: toluene; tetrahydrofuran / 2.17 h

2: lithium chloride / N,N-dimethyl-formamide / 1 h / 120 °C

With lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;