(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

Base Information

Chemical Name:(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide
CAS No.:1287286-60-5
Molecular Formula:C₂₈H₄₁N₃O₂
Molecular Weight:451.652
Hs Code.:

Synonyms:(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

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Chemical Property of (2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

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Technology Process of (2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

There total 7 articles about (2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 7782-24-3
(S)-2-Phenylpropionic acid

: (1R)-1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethanamine tritrifluoroacetate

: 1287286-60-5
(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

Guidance literature:: (S)-2-Phenylpropionic acid; (1R)-1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethanamine tritrifluoroacetate; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1287286-60-5
(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.17 h

1.2: 18 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 - 20 °C

2.2: 0 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

5.1: dichloromethane / 2 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 57591-61-4,68697-60-9,127369-30-6,134694-94-3
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

: 1287286-60-5
(2S)-N-(1-(4-(2-methylpentyloxy)phenyl)-2-(4-methylpiperazin-1-yl)ethyl)-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h

2.2: 18 h / 20 °C

3.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 0 - 20 °C

3.2: 0 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 4 h / 20 °C

6.1: dichloromethane / 2 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;