5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

Base Information

Chemical Name:5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran
CAS No.:140130-22-9
Molecular Formula:C₃₄H₃₂N₂O₆
Molecular Weight:564.638
Hs Code.:

Synonyms:5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

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Chemical Property of 5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

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Technology Process of 5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

There total 9 articles about 5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 140130-21-8
(S)-4-Benzyl-3-{(2S,3R)-2-ethoxy-3-hydroxy-3-[2-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-benzofuran-5-yl]-propionyl}-oxazolidin-2-one

: 140130-22-9
5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

Guidance literature:: With triethylsilane; trifluoroacetic acid; for 96h; Ambient temperature;
DOI:10.1021/jm960230h

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 140130-22-9
5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

2: 1.) dibutylboron triflate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, from -78 to 0 deg C

3: 45 percent / Et₃SiH, TFA / 96 h / Ambient temperature

With pyridine; copper(I) oxide; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; di-n-butylboryl trifluoromethanesulfonate; triethylamine; trifluoroacetic acid;
DOI:10.1021/jm960230h

Reference yield:

: 6813-61-2
2-(benzoylamino)-4-pentynoic acid

: 140130-22-9
5-{(S)-2-Ethoxy-3-[(S)-4-benzyl-2-oxo-3-oxazolidinyl]-3-oxopropyl}-2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]benzofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) H₂O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min

2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

3: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

4: 1.) dibutylboron triflate, Et₃N / 1.) CH₂Cl₂, 0 deg C, 5 min, 2.) CH₂Cl₂, from -78 to 0 deg C

5: 45 percent / Et₃SiH, TFA / 96 h / Ambient temperature

With pyridine; copper(I) oxide; triethylsilane; bis-triphenylphosphine-palladium(II) chloride; di-n-butylboryl trifluoromethanesulfonate; water; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In trifluoroacetic acid;
DOI:10.1021/jm960230h