(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

Base Information

Chemical Name:(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol
CAS No.:914251-60-8
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

Suppliers and Price of (E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

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Technology Process of (E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

There total 4 articles about (E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914251-55-1
(E)-6-(Tetrahydro-pyran-2-yloxy)-hex-2-en-4-yn-1-ol

: 914251-60-8
(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 60 percent / Cs₂CO₃ / acetonitrile

3: 80 percent / Cs₂CO₃ / acetonitrile

4: 70 percent / PPTS / ethanol

With pyridinium p-toluenesulfonate; caesium carbonate; triethylamine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1039/b606653d

Reference yield:

: 914251-54-0
(E)-6-(Tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynoic acid ethyl ester

: 914251-60-8
(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / DIBAL-H / tetrahydrofuran / -78 - 20 °C

2: 80 percent / Et₃N / CH₂Cl₂ / 0 °C

3: 60 percent / Cs₂CO₃ / acetonitrile

4: 80 percent / Cs₂CO₃ / acetonitrile

5: 70 percent / PPTS / ethanol

With pyridinium p-toluenesulfonate; diisobutylaluminium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1039/b606653d

Reference yield:

: 914251-56-2
Methanesulfonic acid (E)-6-(tetrahydro-pyran-2-yloxy)-hex-2-en-4-ynyl ester

: 914251-60-8
(E)-6-{2-[2-(4-Hydroxy-but-2-ynyloxy)-phenylazo]-phenoxy}-hex-4-en-2-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Cs₂CO₃ / acetonitrile

2: 80 percent / Cs₂CO₃ / acetonitrile

3: 70 percent / PPTS / ethanol

With pyridinium p-toluenesulfonate; caesium carbonate; In ethanol; acetonitrile;
DOI:10.1039/b606653d