N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

Base Information

Chemical Name:N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide
CAS No.:1393378-80-7
Molecular Formula:C₂₂H₂₄N₂O₄
Molecular Weight:380.444
Hs Code.:

Synonyms:N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

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Chemical Property of N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

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Technology Process of N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

There total 2 articles about N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₉N₂O₆P

: 94839-07-3
3,4-(methylenedioxy)-benzeneboronic acid

: 1393378-80-7
N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.06.037

Reference yield:

: 1393378-74-9
N-acetyl-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

: 1393378-80-7
N-(1,1,3-benzodioxol-5-ylvinyl)-N-((S)-2-methoxymethylpyrrolidin-1-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 2 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; water; toluene; 2: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.tet.2012.06.037