2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

Base Information

Chemical Name:2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine
CAS No.:1353880-75-7
Molecular Formula:C₂₃H₂₂F₂N₆O₂
Molecular Weight:452.463
Hs Code.:

Synonyms:2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

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Chemical Property of 2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

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Technology Process of 2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

There total 7 articles about 2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: C₂₃H₂₀F₂N₆O₂

: 1353880-75-7
2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1056737-05-3
(2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-2-yl)methanol

: 1353880-75-7
2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 20 - 110 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 18751.9 Torr

3.1: methanol / 12 h / 20 °C / Molecular sieve; Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1353880-69-9
2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-2,4-dimethyl-7-nitro-3,4-dihydro-2H-1,4-benzoxazine

: 1353880-75-7
2-(([1,2,4]triazolo[4,3-b]pyridazin-6-yloxy)methyl)-N-(3,5-difluorobenzyl)-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C / 18751.9 Torr

2: methanol / 12 h / 20 °C / Molecular sieve; Inert atmosphere

3: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; In methanol;