Technology Process of (R)-5-Benzyloxy-2-diazo-4-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-pentanoic acid methyl ester
There total 7 articles about (R)-5-Benzyloxy-2-diazo-4-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyloxy)-pentanoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
p-nitrobenzenesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 0 - 20 ℃;
for 3h;
DOI:10.1021/jo971065w
- Guidance literature:
-
Multi-step reaction with 5 steps
1: NaH, Bu4NI / tetrahydrofuran / 10 h / 0 - 20 °C
2: 1.81 g / HCl / tetrahydrofuran; H2O / 2 h
3: 1.4 g / NaH, methylene blue / 1,2-dimethoxy-ethane / 3 h / 70 °C
4: 1.3 g / NaH, methylene blue / 1,2-dimethoxy-ethane / 10 h / Heating
5: 6.2 g / DBU, PNBSA / CH2Cl2 / 3 h / 0 - 20 °C
With
hydrogenchloride; p-nitrobenzenesulfonic acid; methylene blue; tetra-(n-butyl)ammonium iodide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/jo971065w
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) LiHMDS, 2.) Y(OTf)3 / 1.) toluene, 0 deg C, 30 min, 2.) toluene, 0 deg C, 18 h
2: NaH, Bu4NI / tetrahydrofuran / 10 h / 0 - 20 °C
3: 1.81 g / HCl / tetrahydrofuran; H2O / 2 h
4: 1.4 g / NaH, methylene blue / 1,2-dimethoxy-ethane / 3 h / 70 °C
5: 1.3 g / NaH, methylene blue / 1,2-dimethoxy-ethane / 10 h / Heating
6: 6.2 g / DBU, PNBSA / CH2Cl2 / 3 h / 0 - 20 °C
With
hydrogenchloride; p-nitrobenzenesulfonic acid; methylene blue; tetra-(n-butyl)ammonium iodide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hexamethyldisilazane; yttrium(III) trifluoromethanesulfonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/jo971065w
