(1-Tosylpyrrolidine-2,5-diyl)dimethanol

Base Information

Chemical Name:(1-Tosylpyrrolidine-2,5-diyl)dimethanol
CAS No.:92198-73-7
Molecular Formula:C₁₃H₁₉NO₄S
Molecular Weight:285.364
Hs Code.:
DSSTox Substance ID:DTXSID10699383
Mol file:92198-73-7.mol

Synonyms:(1-TOSYLPYRROLIDINE-2,5-DIYL)DIMETHANOL;92198-73-7;[5-(hydroxymethyl)-1-(4-methylphenyl)sulfonylpyrrolidin-2-yl]methanol;1-[(4-Methylphenyl)sulfonyl]-2,5-pyrrolidinedimethanol;DTXSID10699383;FT-0702353;A898035;[1-(4-Methylbenzene-1-sulfonyl)pyrrolidine-2,5-diyl]dimethanol;[5-(hydroxymethyl)-1-(4-methylbenzenesulfonyl)pyrrolidin-2-yl]methanol

Suppliers and Price of (1-Tosylpyrrolidine-2,5-diyl)dimethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of (1-Tosylpyrrolidine-2,5-diyl)dimethanol

Chemical Property:

Boiling Point:475.9±51.0 °C(Predicted)
PKA:14.47±0.10(Predicted)
PSA：86.22000
Density:1.294±0.06 g/cm3(Predicted)
LogP:1.52000
XLogP3:0.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:285.10347926
Heavy Atom Count:19
Complexity:372

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)N2C(CCC2CO)CO

Technology Process of (1-Tosylpyrrolidine-2,5-diyl)dimethanol

There total 6 articles about (1-Tosylpyrrolidine-2,5-diyl)dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 145472-49-7,145552-03-0
[(S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol

: 92198-73-7,145472-50-0,145552-04-1
[(S)-5-Hydroxymethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: With tetraisobutylammonium fluoride; In tetrahydrofuran; for 2h;
DOI:10.1016/S0040-4020(01)88321-6

Reference yield: 63.0%

: (S)-5-Hydroxymethyl-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester

: 92198-73-7,145472-50-0,145552-04-1
[(S)-5-Hydroxymethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo971192s

Reference yield:

: 132974-84-6
(-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one

: 92198-73-7,145472-50-0,145552-04-1
[(S)-5-Hydroxymethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / DIBAL / CH₂Cl₂ / -78 °C

2: 91 percent / SnCl₄ / CH₂Cl₂ / 1) -78 deg C, 5 h, 2) -20 deg C, 3 h

3: 1) DIBAL, 2) 5percent aq. H₂SO₄ / 1) toluene, hexane, -20 deg C, 1 h, 2) r.t.

4: 72 percent / DIBAL / CH₂Cl₂; hexane / 1 h / -78 °C

5: 90 percent / i-Bu₄NF / tetrahydrofuran / 2 h

With tetraisobutylammonium fluoride; sulfuric acid; tin(IV) chloride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(01)88321-6