methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate
CAS No.:135851-14-8
Molecular Formula:C₁₅H₁₂Cl₃N₃O₂
Molecular Weight:372.638
Hs Code.:

Synonyms:methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

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Technology Process of methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

There total 5 articles about methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

: 135851-13-7
1-ethyl 2-methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-1,2-dicarboxylate

: 135851-14-8
methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

Guidance literature:: With sodium carbonate; In methanol; for 17h; Ambient temperature;
DOI:10.1021/jm00076a004

Reference yield:

: 56961-75-2
2,3,5-trichlorobenzaldehyde

: 135851-14-8
methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / piperidine / pyridine / 8 h

2: NaH / tetrahydrofuran / 1.) from 5 to 10 deg C, 2 h, 2.) RT, overnight

3: 75 percent / NaOAc / H₂O; methanol / 22 h / Ambient temperature

4: 74.7 percent / DBN / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 48 h

5: 89.5 percent / Na₂CO₃ / methanol / 17 h / Ambient temperature

With piperidine; 2,6-dichloro-benzonitrile; sodium acetate; sodium hydride; sodium carbonate; In tetrahydrofuran; pyridine; methanol; dichloromethane; water;
DOI:10.1021/jm00076a004

Reference yield:

: 135851-09-1
3-(2,3,5-trichlorophenyl)pentanedinitrile

: 135851-14-8
methyl 3-amino-4-<2-cyano-1-(2,3,5-trichlorophenyl)ethyl>-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 1.) from 5 to 10 deg C, 2 h, 2.) RT, overnight

2: 75 percent / NaOAc / H₂O; methanol / 22 h / Ambient temperature

3: 74.7 percent / DBN / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 48 h

4: 89.5 percent / Na₂CO₃ / methanol / 17 h / Ambient temperature

With 2,6-dichloro-benzonitrile; sodium acetate; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00076a004