methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate

Base Information

• Chemical Name: methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate
• CAS No.: 937276-19-2
• Molecular Formula: C₃₂H₃₈N₆O₁₀
• Molecular Weight: 666.688

Synonyms:methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate

Chemical Property of methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate

There total 5 articles about methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methyl N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonyl-hydrazino)ethyl]glycinate (937276-24-9) + [N4-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid (144564-95-4) → methyl N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate (937276-19-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; at 0 - 20 ℃; pH=9;

DOI:10.1016/j.tet.2007.02.102

Reference yield:

Nα-(benzyloxycarbonyl)-Nβ-(tert-butoxycarbonyl)-Nβ-(2-hydroxyethyl)hydrazide (937276-26-1) → methyl N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate (937276-19-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.83 h / 20 °C

1.2: methyl tert-butyl ether; NaHCO₃; Na₂S₂O₃ / CH₂Cl₂; H₂O / 0.42 h / 20 °C

2.1: 43 percent / diisopropylethylamine; NaBH₃CN; ZnCl₂ / methanol / 25 h

3.1: 71 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; diisopropylethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 20 °C / pH 9

With sodium cyanoborohydride; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; zinc(II) chloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.02.102

Reference yield:

Nα-(benzyloxycarbonyl)-Nβ-(tert-butoxycarbonyl)-Nβ-(formylmethyl)hydrazide (937276-27-2) → methyl N-[2-(Nα-benzyloxycarbonyl-Nβ-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate (937276-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 43 percent / diisopropylethylamine; NaBH₃CN; ZnCl₂ / methanol / 25 h

2: 71 percent / 3,4-dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; diisopropylethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 20 °C / pH 9

With sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; zinc(II) chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2007.02.102

upstream raw materials:

methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]glycinate

[N⁴-[(benzyloxy)carbonyl]cytosine-1-yl]acetic acid

N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 937276-19-2 methyl N-[2-(N^α-benzyloxycarbonyl-N^β-tert-butoxycarbonyl-hydrazino)ethyl]-N-{[4-N-(benzyloxycarbonyl)cytosin-1-yl]acetyl}glycinate

Send

Send

Metric Ton KG G Pound L ML

Send

Send