(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Chemical Name:(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine
CAS No.:1414875-57-2
Molecular Formula:C₁₆H₁₇ClF₃N₅O
Molecular Weight:387.792
Hs Code.:

Synonyms:(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Chemical Property of (S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

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Technology Process of (S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

There total 6 articles about (S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1357098-11-3
4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde

: 1301740-78-2
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine

: 1414875-57-2
(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carbaldehyde; (S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-oxazin-2-amine; In methanol; at 25 ℃; for 1h; Inert atmosphere;

With methanol; nido-decaborane; at 45 ℃; for 15h;

Reference yield:

: 1357098-10-2
4-chloro-1-(difluoromethyl)-N-methoxy-N-methyl-1H-pyrazole-3-carboxamide

: 1414875-57-2
(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: -15 °C

2.1: methanol / 1 h / 25 °C / Inert atmosphere

2.2: 15 h / 45 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol;

Reference yield:

: 1310351-06-4
4-chloro-1-difluoromethyl-1H-pyrazole-3-carboxylic acid methyl ester

: 1414875-57-2
(S)-4-{5-[(4-chloro-1-difluoromethyl-1H-pyrazol-3-ylmethyl)-amino]-2-fluoro-phenyl}-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 23 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 16 h / 23 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: -15 °C

4.1: methanol / 1 h / 25 °C / Inert atmosphere

4.2: 15 h / 45 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;