C₁₁H₁₂BrNO₂

Base Information

• Chemical Name: C₁₁H₁₂BrNO₂
• CAS No.: 1127389-89-2
• Molecular Formula: C₁₁H₁₂BrNO₂
• Molecular Weight: 270.126
• Mol file: 1127389-89-2.mol

Synonyms:C₁₁H₁₂BrNO₂

Chemical Property of C₁₁H₁₂BrNO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₁H₁₂BrNO₂

There total 1 articles about C₁₁H₁₂BrNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) + glycine ethyl ester hydrochloride (623-33-6) → C11H12BrNO2 (1127389-89-2)

Guidance literature:

glycine ethyl ester hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

m-bromobenzoic aldehyde; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja4122268

Reference yield: 85.0%

C11H12BrNO2 (1127389-89-2) + Phthalazinium dicyanomethanide 1,3-dipole (70704-69-7) → (1S,3S,11bR)-ethyl 3-(3-bromophenyl)-4,4-dicyano-2,3,4,11b-tetrahydro-1H-pyrazino[2,1-a]phthalazine-1-carboxylate

Guidance literature:

With C₂₈H₂₈FeNOP; tetrakis(acetonitrile)copper(I) tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dichloro-ethane; at -20 ℃; for 48h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol503169d

Reference yield: 82.0%

C11H12BrNO2 (1127389-89-2) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → ethyl (2S,4S,5S)-2,5-bis(4-bromophenyl)-1-(2-ethoxy-2-oxoethyl)-3-phenylimidazolidine-4-carboxylate

Guidance literature:

C₁₁H₁₂BrNO₂; With (R)-N,N-dimethyl-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethylamine; silver(I) triflimide; In acetonitrile; at -10 ℃; for 0.5h; Inert atmosphere;

2-(trimethylsilyl)phenyl trifluoromethanesulfonate; With 18-crown-6 ether; cesium fluoride; In acetonitrile; at -10 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1039/c8cc03806f

upstream raw materials:

m-bromobenzoic aldehyde

glycine ethyl ester hydrochloride

Downstream raw materials:

C₁₇H₂₀BrNO₆

(1R,6S,7S,9R)-ethyl 9-(3-bromophenyl)-10-oxo-8-azabicyclo[4.3.1]deca-2,4-diene-7-carboxylate