2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Base Information

Chemical Name:2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide
CAS No.:196937-77-6
Molecular Formula:C₄₃H₅₂N₄O₈SSi
Molecular Weight:813.059
Hs Code.:

2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Synonyms:2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

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Chemical Property of 2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

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Technology Process of 2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

There total 18 articles about 2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2199-43-1
ethyl 1H-pyrrole-2-carboxylate

: 196937-77-6
2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min; 2.) RT, 1 h

2: 85 percent / NaOH / ethanol; H₂O / 5 h / Heating

3: SOCl₂ / 0.1 h / Heating

4: pyridine / benzene / 21 h / Ambient temperature

5: KOH / ethanol; H₂O / 3 h / Heating

6: 1-hydroxybenzotriazole*H₂O / dimethylformamide / 9 h / Ambient temperature

7: (i-Pr)2EtN / CH₂Cl₂ / 20 h / Ambient temperature

8: 54 percent / Bu₄NF*3H₂O / tetrahydrofuran / 1 h / 0 °C

9: Bu₄NClO₄, pyridine / 3 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammonium perchlorate; sodium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.19970800618

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 196937-77-6
2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Guidance literature:: Multi-step reaction with 9 steps

1: 94 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min; 2.) RT, 1 h

2: 85 percent / NaOH / ethanol; H₂O / 5 h / Heating

3: SOCl₂ / 0.1 h / Heating

4: pyridine / benzene / 21 h / Ambient temperature

5: KOH / ethanol; H₂O / 3 h / Heating

6: 1-hydroxybenzotriazole*H₂O / dimethylformamide / 9 h / Ambient temperature

7: (i-Pr)2EtN / CH₂Cl₂ / 20 h / Ambient temperature

8: 54 percent / Bu₄NF*3H₂O / tetrahydrofuran / 1 h / 0 °C

9: Bu₄NClO₄, pyridine / 3 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; thionyl chloride; tetrabutyl ammonium fluoride; tetrabutylammonium perchlorate; sodium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.19970800618

Reference yield:

: 85026-59-1,305384-32-1,780705-82-0
(-)-(1R,2R,3S,4R)-4-amino-2,3-dihydroxy-1-(hydroxymethyl)cyclopentane

: 196937-77-6
2-{[1-(2-Trimethylsilanyl-ethoxymethyl)-1H-pyrrole-2-carbonyl]-amino}-thiazole-5-carboxylic acid {(1R,2S,3R,4R)-4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-2-methoxy-cyclopentyl}-amide

Guidance literature:: Multi-step reaction with 7 steps

1: NaOH / H₂O / 104.5 h / Ambient temperature; pH=13

2: 66 percent / pyridine / dimethylformamide / 5 h / Ambient temperature

3: 69 percent / Ag₂O / 48 h / Heating

4: 56 percent / CF₃COOH, phenol / CH₂Cl₂ / 27 h / Ambient temperature

5: (i-Pr)2EtN / CH₂Cl₂ / 20 h / Ambient temperature

6: 54 percent / Bu₄NF*3H₂O / tetrahydrofuran / 1 h / 0 °C

7: Bu₄NClO₄, pyridine / 3 h / Ambient temperature

With pyridine; sodium hydroxide; tetrabutyl ammonium fluoride; tetrabutylammonium perchlorate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; silver(l) oxide; phenol; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800618