({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

Base Information

Chemical Name:({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid
CAS No.:1008764-31-5
Molecular Formula:C₂₇H₃₄N₄O₆
Molecular Weight:510.59
Hs Code.:

Synonyms:({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

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Chemical Property of ({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

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Technology Process of ({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

There total 8 articles about ({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1008775-37-8
ethyl ({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetate

: 1008764-31-5
({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

Guidance literature:: With methanol; sodium hydroxide; water; In tetrahydrofuran;

Reference yield:

: 219817-42-2
methyl 5-(benzyloxy)nicotinate

: 1008764-31-5
({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: methanol; water / tetrahydrofuran / 0 - 20 °C

2: diphenyl phosphoryl azide; triethylamine / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3: toluene / 2 h / 120 °C

4: triethylamine / tetrahydrofuran; toluene / 12 h / 0 - 20 °C

5: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7: methanol; sodium hydroxide; water / tetrahydrofuran

With methanol; sodium hydroxide; diphenyl phosphoryl azide; water; hydrogen; potassium carbonate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1008775-34-5
5-(benzyloxy)nicotinoylazide

: 1008764-31-5
({5-[({4-[3-(2-cyclohexylethoxy)benzoyl]piperazin-1-yl}carbonyl)amino]pyridin-3-yl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 2 h / 120 °C

2: triethylamine / tetrahydrofuran; toluene / 12 h / 0 - 20 °C

3: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5: methanol; sodium hydroxide; water / tetrahydrofuran

With methanol; sodium hydroxide; water; hydrogen; potassium carbonate; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;