2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester
CAS No.:868964-71-0
Molecular Formula:C₄₁H₆₇N₃O₁₃
Molecular Weight:809.995
Hs Code.:

2-{[2-(bis-<i>tert</i>-butoxycarbonylmethyl-amino)-ethyl]-<i>tert</i>-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-<i>tert</i>-butyl ester

Synonyms:2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

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Chemical Property of 2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

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Technology Process of 2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

There total 6 articles about 2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 868964-65-2
tert-butyl 2-{N-(tert-butyloxycarbonylmethyl)-N-[2-{di(tert-butyloxycarbonylmethyl)amino}ethyl]amino}-4-nitrobutanoate

: 147790-52-1
6-oxohexenoic acid benzyl ester

: 868964-71-0
2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1080/00397910500189718

Reference yield:

: tert-butyl 2-(tert-butyloxycarbonylmethylamino)-3-hydroxypropanoate

: 868964-71-0
2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / diisopropylethylamine / acetonitrile / 20 h / Heating

2: tris(n-butyl)phosphine; diethyl azodicarboxylate / diethyl ether / 3 h / -10 - 20 °C

3: 103 mg / tetrabutylammonium fluoride trihydrate / 20 h / 50 °C

4: 95 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 6 h / 20 °C

With tributylphosphine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; acetonitrile; 3: Michael addition / 4: Henry reaction;
DOI:10.1080/00397910500189718

Reference yield:

: serine tert-butyl ester hydrochloride

: 868964-71-0
2-{[2-(bis-tert-butoxycarbonylmethyl-amino)-ethyl]-tert-butoxycarbonylmethyl-amino}-5-hydroxy-4-nitro-decanedioic acid 10-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / diisopropylethylamine / acetonitrile / 4 h / Heating

2: 87 percent / diisopropylethylamine / acetonitrile / 20 h / Heating

3: tris(n-butyl)phosphine; diethyl azodicarboxylate / diethyl ether / 3 h / -10 - 20 °C

4: 103 mg / tetrabutylammonium fluoride trihydrate / 20 h / 50 °C

5: 95 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 6 h / 20 °C

With tributylphosphine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; acetonitrile; 4: Michael addition / 5: Henry reaction;
DOI:10.1080/00397910500189718