Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

Base Information

Chemical Name:Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate
CAS No.:1292291-28-1
Molecular Formula:C₂₀H₂₃FO₅
Molecular Weight:362.398
Hs Code.:

Synonyms:Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

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Chemical Property of Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

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Technology Process of Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

There total 3 articles about Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1292291-25-8
Ethyl 3-[4-[[4-[(tert-butyl(dimethyl)silyl)oxymethyl]-3-methoxy-phenyl]methoxy]-2-fluoro-phenyl]propanoate

: 1292291-28-1
Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

Guidance literature:: Ethyl 3-[4-[[4-[(tert-butyl(dimethyl)silyl)oxymethyl]-3-methoxy-phenyl]methoxy]-2-fluoro-phenyl]propanoate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 25 ℃; for 2h;

With water; In tetrahydrofuran;

Reference yield:

: 1292291-24-7
[4-(Bromomethyl)-2-methoxy-phenyl]methoxy-tert-butyl-dimethyl-silane

: 1292291-28-1
Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 16 h / 20 - 25 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 25 °C

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; acetonitrile;

Reference yield:

: 1292291-00-9
(4-bromomethyl-2-methoxy-phenyl)-methanol

: 1292291-28-1
Ethyl 3-[2-fluoro-4-[[4-(hydroxymethyl)-3-methoxy-phenyl]methoxy]phenyl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C

2: potassium carbonate / acetonitrile / 16 h / 20 - 25 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 25 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile;