1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one

Base Information

• Chemical Name: 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one
• CAS No.: 223418-24-4
• Molecular Formula: C₁₇H₁₉N₅O₄
• Molecular Weight: 357.369

Synonyms:1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one

Chemical Property of 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one

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Technology Process of 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one

There total 1 articles about 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-((2R,3S)-3-Benzyloxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy)-4-methoxy-pyrimidine (152696-75-8) → 2-((2R,3S)-5-Azido-3-benzyloxy-tetrahydro-furan-2-ylmethoxy)-4-methoxy-pyrimidine + 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one (223418-24-4)

Guidance literature:

2-((2R,3S)-3-Benzyloxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy)-4-methoxy-pyrimidine; With 4 A molecular sieve; dimethyl(methylthio)sulfonium tetrafluoroborate; In acetonitrile; at -20 ℃; for 1h;

With tetrabutylammoniun azide; In acetonitrile; at -20 - 0 ℃; for 3h;

DOI:10.1246/cl.1999.361

Reference yield: 81.0%

1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one (223418-24-4) → 1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:

With Dowex 50W(H+); In ethanol; at 20 ℃;

DOI:10.1246/cl.1999.361

Reference yield: 61.0%

1-((2R,4S,5R)-5-Azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-4-methoxy-1H-pyrimidin-2-one (223418-24-4) → 4-Amino-1-((2R,4S,5R)-5-azidomethyl-4-benzyloxy-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one

Guidance literature:

With ammonia; In methanol; at 80 ℃;

DOI:10.1246/cl.1999.361

upstream raw materials:

2-((2R,3S)-3-Benzyloxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethoxy)-4-methoxy-pyrimidine

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