2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Base Information

Chemical Name:2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one
CAS No.:1417528-85-8
Molecular Formula:C₂₄H₂₀F₃N₅OS
Molecular Weight:483.517
Hs Code.:

Synonyms:2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Chemical Property of 2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

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Technology Process of 2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

There total 9 articles about 2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2290-65-5
trimethylsilyl isothiocyanate

: 1417528-83-6
ethyl 2-((4-((4’-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methylamino)cyclopent-1-enecarboxylate

: 1417528-85-8
2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 140 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.01.029

Reference yield:

: 2290-65-5
trimethylsilyl isothiocyanate

: ethyl 2-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methylamino)cyclopent-1-enecarboxylate

: 1417528-85-8
2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: In N,N-dimethyl-formamide; at 140 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1417528-40-5
(4-(4-bromobenzyl)-4H-1,2,4-triazol-3-yl)methanol

: 1417528-85-8
2-thioxo-1-((4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)-2,3,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Reflux

2: diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Reflux

3: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 20 °C / 760.05 Torr

4: tetraethoxy orthosilicate / ethanol / 5 h / Reflux

5: N,N-dimethyl-formamide / 4 h / 140 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetraethoxy orthosilicate; palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.01.029