Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Base Information

Chemical Name:Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate
CAS No.:334972-46-2
Molecular Formula:C₂₃H₃₄O₅
Molecular Weight:390.52
Hs Code.:

Synonyms:Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Suppliers and Price of Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

There total 7 articles about Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: Ethyl (S)-7-hydroxy-6-(4-methoxybenzyloxy)-2-(4'-methylpent-3'-enyl)hept-2-enoate

: 334972-60-0
Ethyl (S)-2-[(2'S,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

: 334972-58-6
Ethyl (S)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

: 334972-59-7
Ethyl (R)-2-[(2'S,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

: 334972-46-2
Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -10 - -4 ℃;
DOI:10.1016/S0040-4039(00)02179-1

Reference yield:

: 127102-61-8
(S)-hex-5-ene-1,2-diol

: 334972-46-2
Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 85 percent / Et₃N; DMAP / CH₂Cl₂

2.1: 90 percent / TfOH / diethyl ether

3.1: OsO₄; NMO / 2-methyl-propan-2-ol; acetone; H₂O

3.2: 98 percent / NaIO₄; SiO₂ / H₂O; CH₂Cl₂

4.1: 93 percent / t-BuOH / toluene / -20 °C

5.1: 99 percent / PPTS / methanol

6.1: 68 percent / t-BuOK / tetrahydrofuran / -10 - -4 °C

With dmap; osmium(VIII) oxide; N-methyl-2-indolinone; trifluorormethanesulfonic acid; potassium tert-butylate; pyridinium p-toluenesulfonate; triethylamine; tert-butyl alcohol; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; toluene; tert-butyl alcohol; 4.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0040-4039(00)02179-1

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 334972-46-2
Ethyl (R)-2-[(2'R,5'S)-5'-(4-methoxybenzyloxy)tetrahydropyran-2'-yl]-6-methylhept-5-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / TfOH / diethyl ether

2.1: OsO₄; NMO / 2-methyl-propan-2-ol; acetone; H₂O

2.2: 98 percent / NaIO₄; SiO₂ / H₂O; CH₂Cl₂

3.1: 93 percent / t-BuOH / toluene / -20 °C

4.1: 99 percent / PPTS / methanol

5.1: 68 percent / t-BuOK / tetrahydrofuran / -10 - -4 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; trifluorormethanesulfonic acid; potassium tert-butylate; pyridinium p-toluenesulfonate; tert-butyl alcohol; In tetrahydrofuran; methanol; diethyl ether; water; acetone; toluene; tert-butyl alcohol; 3.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/S0040-4039(00)02179-1