3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

Base Information

Chemical Name:3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine
CAS No.:1200129-85-6
Molecular Formula:C₂₂H₂₂N₄
Molecular Weight:342.443
Hs Code.:

Synonyms:3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

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Chemical Property of 3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

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Technology Process of 3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

There total 13 articles about 3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 2-fluoro-5-(4-(piperidin-1-ylmethyl)phenyl)-[3,4′-bipyridin]-3′-amine

: 1200129-85-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-82-0
6-bromo-4-iodonicotinic acid

: 1200129-85-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

Guidance literature:: Multi-step reaction with 5 steps

1: diphenylphosphoranyl azide; triethylamine / toluene / 3 h / 110 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / 1,4-dioxane / 24 h / 110 °C

5: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenylphosphoranyl azide; sodium hexamethyldisilazane; triethylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00464

Reference yield:

: 1200130-83-1
tert-butyl (6-bromo-4-iodopyridin-3-yl)carbamate

: 1200129-85-6
3-(4-(piperidin-1-ylmethyl)phenyl)-9H-pyrrolo[2,3-b:5,4-c′]-dipyridine

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: potassium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; acetonitrile / 4 h / 90 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / 1,4-dioxane / 24 h / 110 °C

4: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1021/acs.jmedchem.5b00464