N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Base Information

Chemical Name:N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol
CAS No.:882048-85-3
Molecular Formula:C₃₄H₄₈F₃NO₅Si
Molecular Weight:635.84
Hs Code.:

Synonyms:N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Suppliers and Price of N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

There total 6 articles about N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 882048-84-2
N-(p-methoxyphenyl)-O-(tetrahydro-2'H-pyran-2'-yl)-N-trifluoroacetyl-α-vinyl-m-tyrosinol

: 13154-24-0
triisopropylsilyl chloride

: 882048-85-3
N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ol060019s

Reference yield:

: 882048-19-3
(E)-3-(3'-tert-butyldimethylsilyloxy)-benzyl-4-O-(tetrahydro-2'H-pyran-2'-yl)-2-buten-1,4-diol

: 882048-85-3
N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / n-butyllithium / tetrahydrofuran / 5.5 h / -78 °C

2: 83 percent / PdCl₂(CH₃CN)2 / benzene / 13.5 h / 20 °C

3: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4: 100 percent / 4-dimethylaminopyridine; imidazole / CH₂Cl₂ / 10 h / 20 °C

With 1H-imidazole; dmap; dichloro bis(acetonitrile) palladium(II); n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol060019s

Reference yield:

: (Z)-3-tributylstannyl-4-tetrahydro-2'H-pyran-2'-yl-2-buten-1,4-diol

: 882048-85-3
N-(p-methoxyphenyl)-O-(tetrahydro-2''H-pyran-2''-yl)-N-trifluoroacetyl-3'-O-triisopropylsilyl-α-vinyl-m-tyrosinol

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / triphenylarsine; Pd₂dba3 / tetrahydrofuran / 6 h / Heating

2: 95 percent / n-butyllithium / tetrahydrofuran / 5.5 h / -78 °C

3: 83 percent / PdCl₂(CH₃CN)2 / benzene / 13.5 h / 20 °C

4: 97 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

5: 100 percent / 4-dimethylaminopyridine; imidazole / CH₂Cl₂ / 10 h / 20 °C

With 1H-imidazole; dmap; dichloro bis(acetonitrile) palladium(II); tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; triphenyl-arsane; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; benzene; 1: Stille coupling;
DOI:10.1021/ol060019s