C₂₁H₂₉NO₄S₂

Base Information

• Chemical Name: C₂₁H₂₉NO₄S₂
• CAS No.: 1310105-98-6
• Molecular Formula: C₂₁H₂₉NO₄S₂
• Molecular Weight: 423.598
• Mol file: 1310105-98-6.mol

Synonyms:C₂₁H₂₉NO₄S₂

Chemical Property of C₂₁H₂₉NO₄S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₉NO₄S₂

There total 6 articles about C₂₁H₂₉NO₄S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S,4R)-5,5-dimethyl-4-phenyl-N-tosyl-1,2,3-oxathiazolidine 2-oxide (620627-47-6) + tert-butylmagnesium bromide (2259-30-5) → C21H29NO4S2 (1310105-98-6)

Guidance literature:

(2S,4R)-5,5-dimethyl-4-phenyl-N-tosyl-1,2,3-oxathiazolidine 2-oxide; tert-butylmagnesium bromide; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; water; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo200715c

Reference yield:

C24H26NO4S2(1-) → C21H29NO4S2 (1310105-98-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; diethyl ether / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: pyridine; thionyl chloride / tetrahydrofuran / -45 °C / Inert atmosphere

3.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

3.2: Inert atmosphere

With pyridine; thionyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; 3.1: Grignard reaction;

DOI:10.1021/jo200715c

Reference yield:

(R)-Phenylglycine methyl ester (24461-61-8) → C21H29NO4S2 (1310105-98-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / ethyl acetate / Inert atmosphere

2.1: tetrahydrofuran / Inert atmosphere

3.1: pyridine; thionyl chloride / tetrahydrofuran / -45 °C / Inert atmosphere

4.1: tetrahydrofuran / -78 - 0 °C / Inert atmosphere

4.2: Inert atmosphere

With pyridine; thionyl chloride; sodium hydrogencarbonate; In tetrahydrofuran; ethyl acetate; 1.1: Schotten-Baumann reaction / 4.1: Grignard reaction;

DOI:10.1021/jo200715c

upstream raw materials:

(2S,4R)-5,5-dimethyl-4-phenyl-N-tosyl-1,2,3-oxathiazolidine 2-oxide

tert-butylmagnesium bromide

C₁₇H₂₁NO₃S

(R)-Phenylglycine methyl ester

Downstream raw materials:

C₁₇H₂₁NO₃S

(R)-2-methylpropane-2-sulfinamide

Refernces