Technology Process of C19H18N2O4
There total 4 articles about C19H18N2O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethyl 3-hydroxy-4-nitrobenzylphosphonate;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
C12H13NO2;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 20 ℃;
for 8h;
Further stages.;
DOI:10.1021/ol990730f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 93 percent / Et3N; CuI / PdCl2(PPh3)2 / tetrahydrofuran / 18 h / 20 °C
2.1: 89 percent / MnO2 / CH2Cl2 / 6 h / 20 °C
3.1: NaHMDS / tetrahydrofuran; dimethylformamide / 1 h / 0 - 20 °C
3.2: 74 percent / tetrahydrofuran; dimethylformamide / 8 h / 20 °C
With
manganese(IV) oxide; copper(l) iodide; sodium hexamethyldisilazane; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
1.1: Heck coupling / 3.2: Wadsworth-Horner-Emmons reaction;
DOI:10.1021/ol990730f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 92 percent / I2; NaHCO3 / CH2Cl2; H2O / 0.5 h / 20 °C
2.1: 93 percent / Et3N; CuI / PdCl2(PPh3)2 / tetrahydrofuran / 18 h / 20 °C
3.1: 89 percent / MnO2 / CH2Cl2 / 6 h / 20 °C
4.1: NaHMDS / tetrahydrofuran; dimethylformamide / 1 h / 0 - 20 °C
4.2: 74 percent / tetrahydrofuran; dimethylformamide / 8 h / 20 °C
With
manganese(IV) oxide; copper(l) iodide; iodine; sodium hexamethyldisilazane; sodium hydrogencarbonate; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
2.1: Heck coupling / 4.2: Wadsworth-Horner-Emmons reaction;
DOI:10.1021/ol990730f
