3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine
CAS No.:1359973-08-2
Molecular Formula:C₁₈H₁₉FN₄
Molecular Weight:310.374
Hs Code.:

Synonyms:3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of 3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

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Technology Process of 3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

There total 3 articles about 3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 904326-92-7
(6-fluoro-5-methylpyridin-3-yl)boronic acid

: 1359973-17-3
3-cyclohexyl-2-iodo-3H-imidazo[4,5-b]pyridine

: 1359973-08-2
3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); cesium fluoride; In methanol; 1,2-dimethoxyethane; at 20 - 110 ℃; for 0.65h; under 1500.15 Torr; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tetlet.2011.12.051

Reference yield:

: 3-cyclohexyl-imidazolo-<4,5-b>-pyridine

: 1359973-08-2
3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1.33 h / -78 °C / Inert atmosphere

2.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); cesium fluoride / methanol; 1,2-dimethoxyethane / 0.65 h / 20 - 110 °C / 1500.15 Torr / Inert atmosphere; Microwave irradiation

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); tert.-butyl lithium; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.12.051

Reference yield:

: 41082-18-2
N²-cyclohexylpyridine-2,3-diamine

: 1359973-08-2
3-cyclohexyl-2-(6-fluoro-5-methylpyridin-3-yl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1.33 h / -78 °C / Inert atmosphere

3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); cesium fluoride / methanol; 1,2-dimethoxyethane / 0.65 h / 20 - 110 °C / 1500.15 Torr / Inert atmosphere; Microwave irradiation

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); tert.-butyl lithium; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 3.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.12.051