2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

Base Information

Chemical Name:2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester
CAS No.:127343-19-5
Molecular Formula:C₄₉H₆₆O₆Si
Molecular Weight:779.145
Hs Code.:

2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

Synonyms:2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

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Chemical Property of 2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

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Technology Process of 2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

There total 6 articles about 2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123049-81-0,79902-63-9
simvastatin

: 127343-19-5
2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) H₂, 2.) thiourea / 1.) (Ph₃P)3RhCl / 1.) toluene, ethanol, 60 psi, RT, 40 h, 2.) toluene, 60 deg C, 1.5

2: imidazole / dimethylformamide / 4 h / 25 °C

3: N-bromosuccinimide, H₂O / tetrahydrofuran; dimethylsulfoxide / 1 h / 5 °C

4: pyridinium chlorochromate (PCC), 4 A sieves / CH₂Cl₂ / 1 h / 0 - 20 °C

5: Zn, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

6: NaBH₄ / tetrahydrofuran; H₂O / 0.58 h / 0 °C

7: (+/-)-camphorsulfonic acid / CH₂Cl₂ / 3 h

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; 4 A molecular sieve; camphor-10-sulfonic acid; water; hydrogen; acetic acid; thiourea; pyridinium chlorochromate; zinc; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a027

Reference yield:

: 126453-95-0
6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-1,2,3,4,6,7,8,8a(R)-octahydronaphtyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

: 127343-19-5
2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 4 h / 25 °C

2: N-bromosuccinimide, H₂O / tetrahydrofuran; dimethylsulfoxide / 1 h / 5 °C

3: pyridinium chlorochromate (PCC), 4 A sieves / CH₂Cl₂ / 1 h / 0 - 20 °C

4: Zn, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

5: NaBH₄ / tetrahydrofuran; H₂O / 0.58 h / 0 °C

6: (+/-)-camphorsulfonic acid / CH₂Cl₂ / 3 h

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; 4 A molecular sieve; camphor-10-sulfonic acid; water; acetic acid; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a027

Reference yield:

: 2,2-Dimethyl-butyric acid (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl ester

: 127343-19-5
2,2-Dimethyl-butyric acid (1S,3R,4R,4aR,7S,8S,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-diphenyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-4-((E)-styryloxy)-decahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-bromosuccinimide, H₂O / tetrahydrofuran; dimethylsulfoxide / 1 h / 5 °C

2: pyridinium chlorochromate (PCC), 4 A sieves / CH₂Cl₂ / 1 h / 0 - 20 °C

3: Zn, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

4: NaBH₄ / tetrahydrofuran; H₂O / 0.58 h / 0 °C

5: (+/-)-camphorsulfonic acid / CH₂Cl₂ / 3 h

With sodium tetrahydroborate; N-Bromosuccinimide; 4 A molecular sieve; camphor-10-sulfonic acid; water; acetic acid; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jm00112a027