5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide

Base Information

• Chemical Name: 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide
• CAS No.: 1351565-11-1
• Molecular Formula: C₁₇H₁₃F₄N₃O₂
• Molecular Weight: 367.303
• Mol file: 1351565-11-1.mol

Synonyms:5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide

Chemical Property of 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide

There total 3 articles about 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-cyano-2-fluoro-benzoic acid (4-methoxy-2-trifluoromethylbenzylidene)hydrazide (1351565-10-0) → 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide (1351565-11-1)

Guidance literature:

5-cyano-2-fluoro-benzoic acid (4-methoxy-2-trifluoromethylbenzylidene)hydrazide; With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

4-methoxy-2-(trifluoromethyl)benzaldehyde (106312-36-1) → 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide (1351565-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C

With triethylsilane; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

(5-cyano-2-fluorobenzoyl)hydrazine (1351565-09-7) → 5-cyano-2-fluorobenzoic acid 2-(4-methoxy-2-trifluoromethylbenzyl)hydrazide (1351565-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h / Reflux

2: trifluoroacetic acid; triethylsilane / dichloromethane / 3 h / 20 °C

With triethylsilane; trifluoroacetic acid; In ethanol; dichloromethane;

upstream raw materials:

4-methoxy-2-(trifluoromethyl)benzaldehyde

(5-cyano-2-fluorobenzoyl)hydrazine

5-cyano-2-fluoro-benzoic acid (4-methoxy-2-trifluoromethylbenzylidene)hydrazide

Downstream raw materials:

3-hydroxy-1-(4-methoxy-2-trifluoromethylbenzyl)-1H-indazole-5-carbonitrile