Technology Process of 4-vinylbenzyl 4-(5-(4-tridecylphenyl)-1,3,4-oxadiazol-2-yl)benzoate
There total 13 articles about 4-vinylbenzyl 4-(5-(4-tridecylphenyl)-1,3,4-oxadiazol-2-yl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(5-(4-tridecylphenyl)-1,3,4-oxadiazol-2-yl)benzoic acid;
With
sodium hydrogencarbonate;
In
N,N-dimethyl-formamide;
for 1h;
Inert atmosphere;
4-Vinylbenzyl chloride;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 15h;
DOI:10.1002/chem.201202246
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C
2.1: hydrogenchloride / water / 1 h / Reflux
2.2: 1 h / Reflux
3.1: sulfuric acid / Reflux
4.1: hydrazine hydrate / ethanol / 48 h / Reflux
5.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
5.2: 0.5 h / Inert atmosphere
6.1: trichlorophosphate / 4 h / 85 °C
7.1: potassium hydroxide / tetrahydrofuran; water; methanol / Reflux
8.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / Inert atmosphere
8.2: 15 h / 60 °C
With
hydrogenchloride; n-butyllithium; sulfuric acid; sodium hydrogencarbonate; hydrazine hydrate; diisopropylamine; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; hexane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201202246
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / Reflux
2.1: hydrazine hydrate / ethanol / 48 h / Reflux
3.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
4.1: trichlorophosphate / 4 h / 85 °C
5.1: potassium hydroxide / tetrahydrofuran; water; methanol / Reflux
6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 1 h / Inert atmosphere
6.2: 15 h / 60 °C
With
sulfuric acid; sodium hydrogencarbonate; hydrazine hydrate; potassium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201202246
