2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

Base Information

Chemical Name:2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester
CAS No.:858972-93-7
Molecular Formula:C₃₀H₄₀N₂O₇
Molecular Weight:540.657
Hs Code.:

Synonyms:2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

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Chemical Property of 2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

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Technology Process of 2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

There total 1 articles about 2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: (R)-2-(2-Methylamino-acetoxy)-3-phenyl-propionic acid benzyl ester; compound with trifluoro-acetic acid

: 858972-93-7
2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 12h;
DOI:10.3390/10010259

Reference yield:

: 858972-93-7
2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

: (R)-2-{2-[((2S,3R)-2-tert-Butoxycarbonylamino-3-methyl-pentanoyl)-methyl-amino]-acetoxy}-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h;
DOI:10.3390/10010259

Reference yield:

: 858972-93-7
2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenylpropionic acid benzyl ester

: 858972-92-6
2-(2-{[2-(2-{2-[(2-tert-butoxycarbonylamino-3-methylpentanoyl)methylamino]acetoxy}-3-phenyl-propionylamino)-3-methylpentanoyl]methylamino}acetoxy)-3-phenylpropionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / Pd-C / ethyl acetate / 12 h / 20 °C

2: 0.16 g / bis(2-oxo-3-oxazolidinyl)-phosphinic chloride; triethylamine / CH₂Cl₂ / 12 h / 20 °C

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.3390/10010259