(R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate

Base Information

Chemical Name:(R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate
CAS No.:88000-56-0
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:(R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate

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Chemical Property of (R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate

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Technology Process of (R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate

There total 16 articles about (R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 126828-58-8
(R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-nitrophenyl)-α-phenyl acetate

: 88000-56-0
(R)-(-)-1-azabicyclo<2.2.2>oct-3-yl-(R)-(+)-α-hydroxy-α-(4-aminophenyl)-α-phenyl acetate

Guidance literature:: With hydrogen; palladium-polyethylenimine; In methanol; for 72h; under 2280 Torr; Ambient temperature;
DOI:10.1002/jps.2600781011

Reference yield:

: 81039-78-3
ethyl α-hydroxy-α-(4-aminophenyl)-α-phenylacetate

: 3684-26-2,25333-42-0,34583-34-1,1619-34-7
(S)-quinuclidin-3-ol

: 81039-90-9,88000-56-0,88000-57-1,88000-61-7,88000-62-8
(S)-(+)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate

Guidance literature:: With sodium; Yield given. Multistep reaction; 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 24 h;
DOI:10.1021/jm00368a009

Reference yield:

: 1144-74-7
4-nitrobenzophenone

: 81039-90-9,88000-56-0,88000-57-1,88000-61-7,88000-62-8
(S)-(+)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: ZnI₂ / CH₂Cl₂ / 72 h / Ambient temperature

2: 3 N aq. HCl / 24 h / Ambient temperature

3: 1.) K₂CO₃, dicyclohexano-18-crown-6 / 1.) acetonitrile, RT, 0.5 h, 2.) acetonitrile, RT, 96 h

4: 100 percent / H₂ / Pd-polyethylamine / methanol / 24 h / 2280 Torr

5: 1.) Na / 1.) benzene, reflux, 0.5 h, 2.) benzene, reflux, 24 h

With hydrogenchloride; perhydrodibenzo-18-crown-6; hydrogen; sodium; potassium carbonate; zinc(II) iodide; Pd-polyethylamine; In methanol; dichloromethane;
DOI:10.1021/jm00368a009