6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline
CAS No.:1350895-86-1
Molecular Formula:C₂₅H₂₃NO₂
Molecular Weight:369.463
Hs Code.:

Synonyms:6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

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Technology Process of 6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1132765-72-0
6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

: 536-74-3
phenylacetylene

: 1350895-86-1
6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: 6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline; With tris(2,2'-bipyridyl)ruthenium dichloride; Bromotrichloromethane; In N,N-dimethyl-formamide; for 3h; Inert atmosphere; Irradiation;

phenylacetylene; With triethylamine; copper(I) bromide; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol202883v

Reference yield: 78.0%

: 132283-68-2
2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde

: 536-74-3
phenylacetylene

: 62-53-3
aniline

: 1350895-86-1
6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; zinc(II) chloride; In toluene; at 110 ℃; for 3h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetlet.2017.04.008

Reference yield:

: 1132765-72-0
6,7-dimethoxy-2-phenyl-1,2,3,4-tetrahydroisoquinoline

: 1350895-86-1
6,7-[dimethoxy-2-phenyl-1-(phenylethynyl)]-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: tris(bipyridine)ruthenium(II) dichloride hexahydrate / acetonitrile / Flow reactor; Irradiation

2: copper(I) triflate benzene complex / dichloromethane

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; copper(I) triflate benzene complex; In dichloromethane; acetonitrile;
DOI:10.1039/d0ob02582h