3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

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Chemical Name:3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide
CAS No.:1186421-50-0
Molecular Formula:C₂₅H₂₀FN₅O₃S
Molecular Weight:489.53
Hs Code.:

Synonyms:3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

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Chemical Property of 3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

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Technology Process of 3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

There total 3 articles about 3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1186421-47-5
3-[3-(4-fluoro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

: 1186421-50-0
3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

Guidance literature:: 3-[3-(4-fluoro-3-methoxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide; With boron tribromide; In dichloromethane; at 0 ℃; for 1.5h;

With sodium hydrogencarbonate; Saturated solution; Cooling with ice;

Reference yield:

: 1310456-95-1
3-(3-(dimethylamino)acryloyl)-N,N-dimethylbenzenesulfonamide

: 1186421-50-0
3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 1 h / 80 °C

2.1: boron tribromide / dichloromethane / 1.5 h / 0 °C

2.2: Saturated solution; Cooling with ice

With boron tribromide; acetic acid; In dichloromethane;

Reference yield:

: 173158-15-1
3-acetyl-N,N-dimethylbenzenesulfonamide

: 1186421-50-0
3-[3-(4-fluoro-3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-N,N-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 °C

2.1: acetic acid / 1 h / 80 °C

3.1: boron tribromide / dichloromethane / 1.5 h / 0 °C

3.2: Saturated solution; Cooling with ice

With boron tribromide; acetic acid; In dichloromethane;