(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

Base Information

Chemical Name:(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate
CAS No.:142219-16-7
Molecular Formula:C₃₀H₃₃ClN₄O₅S
Molecular Weight:597.135
Hs Code.:

Synonyms:(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

There total 8 articles about (R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114799-92-7
2-Butyl-4-chloro-1-[(4-nitrophenyl)methyl]-1H-imidazole-5-methanol

: 142219-16-7
(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) SO₂Cl₂, 2.) n-Bu₄NBr / 1.) CHCl₃, reflux, 3 h, 2.) CHCl₃, H₂O, RT, 2 h

2: 6 N aq. HCl / 3 h / Heating

3: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

4: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

5: 1.) triethyl amine, tert-butylacetyl chloride / 1.) THF, 2 h, 2.) THF, RT, 18 h

With hydrogenchloride; sulfuryl dichloride; 3,3-dimethylbutanoic acid chloride; tetrabutylammomium bromide; hydrogen; triethylamine; trimethyl orthoformate; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 114771-99-2
2-Butyl-4-chloro-5-(cyanomethyl]-l-[(4-nitrophenyl)-methyl]imidazole

: 142219-16-7
(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 6 N aq. HCl / 3 h / Heating

2: 6.0 g / HCl (g), CH(OMe)3 / 3 h / Heating

3: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

4: 1.) triethyl amine, tert-butylacetyl chloride / 1.) THF, 2 h, 2.) THF, RT, 18 h

With hydrogenchloride; 3,3-dimethylbutanoic acid chloride; hydrogen; triethylamine; trimethyl orthoformate; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007

Reference yield:

: 114772-04-2
methyl 2-n-butyl-4-chloro-1-<(4-nitrophenyl)methyl>imidazole-5-acetate

: 142219-16-7
(R,S)-methyl 2-butyl-5-chloro-3-<<4-<<2-<2-(methoxycarbonyl)-1H-pyrrol-1-yl>-1-oxo-3-(2-thienyl)propyl>amino>phenyl>methyl>-3H-imidazole-4-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

2: 1.) triethyl amine, tert-butylacetyl chloride / 1.) THF, 2 h, 2.) THF, RT, 18 h

With 3,3-dimethylbutanoic acid chloride; hydrogen; triethylamine; nickel; In tetrahydrofuran;
DOI:10.1021/jm00064a007