(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

Base Information

Chemical Name:(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride
CAS No.:1057443-06-7
Molecular Formula:C₃₂H₄₀N₆O₂*ClH
Molecular Weight:577.17
Hs Code.:

Synonyms:(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

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Chemical Property of (S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

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Technology Process of (S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

There total 12 articles about (S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1057443-13-6
(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea

: 1057443-06-7
(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

Guidance literature:: With hydrogenchloride;

Reference yield:

: 123-00-2
4-(3-Aminopropyl)morpholine

: 1057443-06-7
(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,2-dichloro-ethane / 18 h / 65 °C

1.2: 1 h / 0 - 20 °C

2.1: triethylamine / ethyl acetate / 18 h / 20 °C

3.1: lithium borohydride / methanol; diethyl ether / 2 h / 35 °C

4.1: Dess-Martin periodane / dichloromethane / 18 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 65 °C

6.1: hydrogenchloride

With hydrogenchloride; lithium borohydride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; triethylamine; acetic acid; In methanol; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1057489-03-8
(S)-methyl 4-((1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)ureido)methyl)benzoate

: 1057443-06-7
(S)-1-(4-(((1H-imidazol-2-yl)methylamino)methyl)benzyl)-1-(3-morpholinopropyl)-3-(1-(naphthalen-1-yl)ethyl)urea monohydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: lithium borohydride / methanol; diethyl ether / 2 h / 35 °C

2: Dess-Martin periodane / dichloromethane / 18 h / 20 °C

3: sodium tris(acetoxy)borohydride / acetic acid / 1,2-dichloro-ethane / 18 h / 65 °C

4: hydrogenchloride

With hydrogenchloride; lithium borohydride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; acetic acid; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane;