(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

Base Information

Chemical Name:(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine
CAS No.:197654-69-6
Molecular Formula:C₂₇H₃₅N₃O₃
Molecular Weight:449.593
Hs Code.:

Synonyms:(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

Chemical Property:

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Technology Process of (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

There total 3 articles about (2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(1-Cyanoethyl)-2-methoxybenzaldehyde

: 187679-58-9
(2S,3S)-3-Amino-1-tert-butoxycarbonyl-2-phenylpiperidine

: 197654-69-6
(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

Guidance literature:: With NaBH(OAc)3; In dichloromethane;

Reference yield:

: 136982-36-0
(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine

: 197654-69-6
(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide

2: Pd(OH)2 / methanol

3: NaBH(OAc)3 / dichloromethane

With sodium hydroxide; NaBH(OAc)3; Pd(OH)2; In methanol; dichloromethane;

Reference yield:

: 187679-57-8
tert-butyl (2S,3S)-3-({[2-(methyloxy)phenyl]methyl}amino)-2-phenylpiperidinecarboxylate

: 197654-69-6
(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(OH)2 / methanol

2: NaBH(OAc)3 / dichloromethane

With NaBH(OAc)3; Pd(OH)2; In methanol; dichloromethane;