(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

Base Information

Chemical Name:(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one
CAS No.:1429176-19-1
Molecular Formula:C₂₄H₂₆N₄O₂
Molecular Weight:402.496
Hs Code.:

Synonyms:(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

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Chemical Property of (S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

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Technology Process of (S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

There total 3 articles about (S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1429180-81-3
(S)-3-(2-chloropyrimidin-4-yl)-4-isopropyl-oxazolidin-2-one

: 55005-32-8,1354970-76-5
1-(biphenyl-4-yl)ethanamine hydrochloride

: 1429176-19-1
(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 2h;
DOI:10.1021/acsmedchemlett.6b00334

Reference yield:

: 1429180-81-3
(S)-3-(2-chloropyrimidin-4-yl)-4-isopropyl-oxazolidin-2-one

: 55005-32-8,1354970-76-5
1-(biphenyl-4-yl)ethanamine hydrochloride

: 1429176-18-0
C₂₄H₂₆N₄O₂

: 1429176-19-1
(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 2h;

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 1429176-19-1
(S)-3-(2-((S)-1-(biphenyl-4-yl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2 h / 110 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acsmedchemlett.6b00334