4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid

Base Information

• Chemical Name: 4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid
• CAS No.: 330580-55-7
• Molecular Formula: C₁₆H₁₄N₂O₄
• Molecular Weight: 298.298
• Mol file: 330580-55-7.mol

Synonyms:4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid

Chemical Property of 4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid

There total 1 articles about 4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-methyl-1-benzoylhydrazine (1483-24-5) + 4-formyl-3-hydroxybenzoic acid (619-12-5) → 4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid (330580-55-7)

Guidance literature:

In methanol; for 16h; Heating;

DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j

Reference yield: 55.0%

4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid (330580-55-7) → 4-[(2-benzoyl-2-methylhydrazino)methyl]-3-hydroxybenzoic acid (330580-56-8)

Guidance literature:

With sodium cyanoborohydride; trifluoroacetic acid; In ethanol; at 20 ℃; for 18h;

DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j

Reference yield:

4-[(2-benzoyl-2-methylhydrazono)methyl]-3-hydroxybenzoic acid (330580-55-7) → 3-[benzoyl(methyl)amino]-3,4-dihydro-2-oxo-2H-1,3-benzoxazine-7-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NaBH₃CN; CF₃CO₂H / ethanol / 18 h / 20 °C

2: 68 percent / Et₃N / tetrahydrofuran / 4 h / Heating

With sodium cyanoborohydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol;

DOI:10.1002/1099-0690(200101)2001:1<141::aid-ejoc141>3.0.co;2-j

upstream raw materials:

1-methyl-1-benzoylhydrazine

4-formyl-3-hydroxybenzoic acid

Downstream raw materials:

4-[(2-benzoyl-2-methylhydrazino)methyl]-3-hydroxybenzoic acid