tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

Base Information

Chemical Name:tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate
CAS No.:1226852-38-5
Molecular Formula:C₃₈H₃₈BrN₃O₄
Molecular Weight:680.641
Hs Code.:

Synonyms:tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

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Chemical Property of tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

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Technology Process of tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

There total 1 articles about tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181484-89-9
(S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1226852-38-5
tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

Guidance literature:: 2-(4-bromophenyl)-acetic acid; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

(S)-2-tert-Butoxycarbonylamino-3-{1-[(4-methoxy-phenyl)-diphenyl-methyl]-1H-imidazol-4-yl}-propionic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c1ob05149k

Reference yield:

: 1226852-38-5
tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

: 5720-05-8
4-methylphenylboronic acid

: C₄₅H₄₅N₃O₄

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 12h; Inert atmosphere; Reflux;
DOI:10.1039/c1ob05149k

Reference yield:

: 1226852-38-5
tert-butyl [(1S)-3-(4-bromophenyl)-1-({1-[(4-methoxyphenyl)(diphenyl)methyl]-1H-imidazol-4-yl}methyl)-2-oxopropyl]carbamate

: 536-74-3
phenylacetylene

: C₄₆H₄₃N₃O₄

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine; In tetrahydrofuran; for 12h; Inert atmosphere; Reflux;
DOI:10.1039/c1ob05149k