4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

Base Information

• Chemical Name: 4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE
• CAS No.: 91996-78-0
• Molecular Formula: C₇H₅N₃OS
• Molecular Weight: 179.202
• Mol file: 91996-78-0.mol

Synonyms:Pyrido[2,3-d]pyrimidin-2-ol,4-mercapto- (7CI)

Chemical Property of 4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

Chemical Property:

• PSA: 93.63000
• LogP: 0.98070

Purity/Quality:

97% ^*data from raw suppliers

4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE

There total 5 articles about 4-THIOXO-3,4-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-3H-pyrido[2,3-d]pyrimidine-4-thione (91996-76-8) → 4-thioxo-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one (91996-78-0)

Guidance literature:

With sodium acetate; acetic acid;

DOI:10.1021/ja01613a069

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) → 4-thioxo-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one (91996-78-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 190 °C

2: POCl₃

3: H₂O; NaHS

4: aqueous acetic acid; sodium acetate

With sodium hydrogensulfide; water; sodium acetate; acetic acid; trichlorophosphate;

DOI:10.1021/ja01613a069

Reference yield:

N-(2-pyridyl-3-methyl)acetamide (7463-30-1) → 4-thioxo-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one (91996-78-0)

Guidance literature:

Multi-step reaction with 5 steps

1: aqueous KMnO₄ / Erwaermen des Reaktionsprodukts mit wss. HCl

2: 190 °C

3: POCl₃

4: H₂O; NaHS

5: aqueous acetic acid; sodium acetate

With potassium permanganate; sodium hydrogensulfide; water; sodium acetate; acetic acid; trichlorophosphate;

DOI:10.1021/ja01613a069

upstream raw materials:

2-chloro-3H-pyrido[2,3-d]pyrimidine-4-thione

2-aminopyridin-3-carboxylic acid

N-(2-pyridyl-3-methyl)acetamide

2,4-dichloropyrido[2,3-d]pyrimidine