2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide

Base Information

• Chemical Name: 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide
• CAS No.: 1616260-85-5
• Molecular Formula: C₁₃H₁₃N₅O₄
• Molecular Weight: 303.277
• Mol file: 1616260-85-5.mol

Synonyms:2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide

Chemical Property of 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide

There total 4 articles about 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-methyl-4-nitropyrrole-2-carboxylic acid hydrazide (28494-50-0) + phenyl isocyanate (103-71-9) → 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide (1616260-85-5)

Guidance literature:

In ethanol; N,N-dimethyl-formamide; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2014.05.018

Reference yield:

N-Methylpyrrole (96-54-8) → 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide (1616260-85-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / diethyl ether

2: nitric acid; acetic anhydride / 2 h / -10 °C

3: hydrazine hydrate / ethanol / 2 h / 20 °C

4: ethanol; N,N-dimethyl-formamide / Inert atmosphere; Reflux

With nitric acid; acetic anhydride; potassium carbonate; hydrazine hydrate; In diethyl ether; ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.05.018

Reference yield:

1-methyl-2-trichloroacetyl-1H-pyrrole (21898-65-7) → 2-(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-N-phenylhydrazinecarboxamide (1616260-85-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; acetic anhydride / 2 h / -10 °C

2: hydrazine hydrate / ethanol / 2 h / 20 °C

3: ethanol; N,N-dimethyl-formamide / Inert atmosphere; Reflux

With nitric acid; acetic anhydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.05.018

upstream raw materials:

1-methyl-4-nitropyrrole-2-carboxylic acid hydrazide

phenyl isocyanate

N-Methylpyrrole

1-methyl-2-trichloroacetyl-1H-pyrrole