3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester

Base Information

• Chemical Name: 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester
• CAS No.: 851181-40-3
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 851181-40-3.mol

Synonyms:3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester

Chemical Property of 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester

There total 4 articles about 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 2-[(4-hydroxyphenyl)methyl]-3-oxopentanoate (361576-47-8) + O-ethylhydroxylamine hydrochloride (3332-29-4) → 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester (851181-40-3)

Guidance literature:

With sodium acetate; In methanol; at 20 ℃; for 5h;

Reference yield:

3-(4-hydroxy-phenyl)-2-propionyl-acrylic acid methyl ester → 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester (851181-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / Pd(OH)2 / methanol; ethyl acetate

2: 90 percent / NaOAc / methanol

With hydrogen; sodium acetate; palladium dihydroxide; In methanol; ethyl acetate;

DOI:10.1016/j.bmcl.2006.11.050

Reference yield:

methyl propanoyl acetate (30414-53-0) → 3-ethyloxyimino-2-(4-hydroxy-benzyl)-pentanoic acid methyl ester (851181-40-3)

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine; AcOH / benzene / Heating

2: 95 percent / H₂ / Pd(OH)2 / methanol; ethyl acetate

3: 90 percent / NaOAc / methanol

With hydrogen; sodium acetate; piperidine; palladium dihydroxide; acetic acid; In methanol; ethyl acetate; benzene;

DOI:10.1016/j.bmcl.2006.11.050

upstream raw materials:

methyl 2-[(4-hydroxyphenyl)methyl]-3-oxopentanoate

O-ethylhydroxylamine hydrochloride

methyl propanoyl acetate

4-hydroxy-benzaldehyde

Downstream raw materials:

3-ethoxyimino-2-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-pentanoic acid methyl ester