(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

Base Information

Chemical Name:(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate
CAS No.:219922-32-4
Molecular Formula:C₂₉H₃₂N₂O₃
Molecular Weight:456.585
Hs Code.:

(S)-(-)-ethyl 4-<2-<<phenyl-<2-(1-piperidinyl)phenyl>methyl>amino>-2-oxoethyl>-benzoate

Synonyms:(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

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Technology Process of (S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

There total 10 articles about (S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 67097-50-1
{4-[(ethyloxy)carbonyl]phenyl}acetic acid

: 219922-10-8
(S)-phenyl-(2-(1-piperidinyl)phenyl)-methylamine

: 219922-32-4
(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: With tetrachloromethane; triethylamine; triphenylphosphine; In acetonitrile; for 15h; Ambient temperature;
DOI:10.1021/jm9810349

Reference yield:

: 72752-52-4
2-(piperidin-1-yl)benzonitrile

: 219922-32-4
(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; toluene / 3 h / Heating

2: NaBH₄ / methanol / 2 h / 15 °C

3: 1.) n-BuLi / 1.) THF, hexane, -15 deg C, 5 min, 2.) THF, hexane, RT, overnight

4: 97 percent / CF₃CO₂H, MeOH / 1.75 h / 30 - 40 °C

5: 72 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With methanol; tetrachloromethane; sodium tetrahydroborate; n-butyllithium; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1021/jm9810349

Reference yield:

: 110-89-4
piperidine

: 219922-32-4
(S)-(-)-ethyl 4-<2-<methyl>amino>-2-oxoethyl>-benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / N-formyl-piperidine / 64 h / 160 - 170 °C

2: tetrahydrofuran; toluene / 3 h / Heating

3: NaBH₄ / methanol / 2 h / 15 °C

4: 1.) n-BuLi / 1.) THF, hexane, -15 deg C, 5 min, 2.) THF, hexane, RT, overnight

5: 97 percent / CF₃CO₂H, MeOH / 1.75 h / 30 - 40 °C

6: 72 percent / PPh₃, Et₃N, CCl₄ / acetonitrile / 15 h / Ambient temperature

With N-Formylpiperidine; methanol; tetrachloromethane; sodium tetrahydroborate; n-butyllithium; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; toluene; acetonitrile;
DOI:10.1021/jm9810349