C₂₁H₂₃F₂NO₃

Base Information

Chemical Name:C₂₁H₂₃F₂NO₃
CAS No.:1352954-30-3
Molecular Formula:C₂₁H₂₃F₂NO₃
Molecular Weight:375.415
Hs Code.:

C<sub>21</sub>H<sub>23</sub>F<sub>2</sub>NO<sub>3</sub>

Synonyms:C₂₁H₂₃F₂NO₃

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Chemical Property of C₂₁H₂₃F₂NO₃

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Technology Process of C₂₁H₂₃F₂NO₃

There total 3 articles about C₂₁H₂₃F₂NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 3422-01-3
tert-butyl phenylcarbamate

: 1352954-26-7
C₁₂H₁₅F₂NO₂

: 1352954-30-3
C₂₁H₂₃F₂NO₃

Guidance literature:: tert-butyl phenylcarbamate; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 - -20 ℃; for 2.25h; Inert atmosphere;

C₁₂H₁₅F₂NO₂; In tetrahydrofuran; pentane; at -20 - 0 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/anie.201105138

Reference yield:

: 139063-68-6
ethyl 2,2-difluoro-4-phenylbutanoate

: 1352954-30-3
C₂₁H₂₃F₂NO₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2.25 h / -78 - -20 °C / Inert atmosphere

2.2: 1.5 h / -20 - 0 °C / Inert atmosphere

With tert.-butyl lithium; isopropylmagnesium chloride; In tetrahydrofuran; pentane;
DOI:10.1002/anie.201105138

Reference yield:

: 64920-29-2
2-oxo-4-phenylbutanoic acid ethyl ester

: 1352954-30-3
C₂₁H₂₃F₂NO₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylammonium dihydrofluoride; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 24 h / 20 °C / Inert atmosphere

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 2.25 h / -78 - -20 °C / Inert atmosphere

3.2: 1.5 h / -20 - 0 °C / Inert atmosphere

With tert.-butyl lithium; isopropylmagnesium chloride; triethylammonium dihydrofluoride; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1002/anie.201105138