(R)-(4-hydroxyphenyl)(phenylacetamido)acetic acid

Base Information

• Chemical Name: (R)-(4-hydroxyphenyl)(phenylacetamido)acetic acid
• CAS No.: 54582-01-3
• Molecular Formula: C16H15NO4
• Molecular Weight: 285.299
• Hs Code.: 2924299090
• Mol file: 54582-01-3.mol

Synonyms:(R)-(4-Hydroxyphenyl)(phenylacetamido)acetic acid;(2R)-(4-Hydroxyphenyl)[(phenylacetyl)amino]ethanoic acid;(R)-2-(4-Hydroxyphenyl)-2-(phenylacetylamino)acetic acid;(R)-4-Hydroxy-α-[(phenylacetyl)amino]benzeneacetic acid;

Chemical Property of (R)-(4-hydroxyphenyl)(phenylacetamido)acetic acid

Chemical Property:

• Vapor Pressure: 5.9E-15mmHg at 25°C
• Refractive Index: 1.628
• Boiling Point: 594 °C at 760 mmHg
• Flash Point: 313 °C
• PSA: 90.12000
• Density: 1.322 g/cm³
• LogP: 2.71710

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-(4-hydroxyphenyl)(phenylacetamido)acetic acid

There total 1 articles about (R)-(4-hydroxyphenyl)(phenylacetamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenylacetyl-(4-hydroxyphenyl)-glycine (54713-12-1,84709-13-7) → phenylacetic acid (103-82-2) + (R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine (54582-01-3,84709-13-7) + D-4-hydroxyphenylglycine (22818-40-2) + (S)-hydroxyphenylglycine (32462-30-9)

Guidance literature:

With penicillin G acylase; water; sodium carbonate; for 0.333333h; pH=8.0; optical yield given as %ee; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/adsc.200800203

Reference yield: 93.0%

(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine (54582-01-3,84709-13-7) → D-4-hydroxyphenylglycine (22818-40-2)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 10h;

DOI:10.1002/adsc.200800203

upstream raw materials:

N-phenylacetyl-(4-hydroxyphenyl)-glycine

Downstream raw materials:

D-4-hydroxyphenylglycine