N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide

Base Information

• Chemical Name: N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide
• CAS No.: 1345732-32-2
• Molecular Formula: C₁₉H₁₆ClN₅O
• Molecular Weight: 365.822

Synonyms:N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide

Chemical Property of N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide

Chemical Property:

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Technology Process of N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide

There total 3 articles about N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (E)-N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)cinnamamide (1345732-14-0) → N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide (1345732-32-2)

Guidance literature:

With triethylamine; In diethyl ether; dichloromethane; at -20 - -15 ℃;

DOI:10.1016/j.ejmech.2011.08.032

Reference yield:

Cinnamoyl chloride (102-92-1,17082-09-6) → N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide (1345732-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Reflux

2: triethylamine / diethyl ether; dichloromethane / -20 - -15 °C

With triethylamine; In diethyl ether; dichloromethane; toluene;

DOI:10.1016/j.ejmech.2011.08.032

Reference yield:

4-(4-chlorophenyl)-1H-imidazol-2-ylamine (60472-18-6) → N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4',5'-dihydro-4'-phenyl-1'H-pyrazole-3'-carboxamide (1345732-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Reflux

2: triethylamine / diethyl ether; dichloromethane / -20 - -15 °C

With triethylamine; In diethyl ether; dichloromethane; toluene;

DOI:10.1016/j.ejmech.2011.08.032

upstream raw materials:

diazomethane

(E)-N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)cinnamamide

Cinnamoyl chloride

4-(4-chlorophenyl)-1H-imidazol-2-ylamine

Downstream raw materials:

N-(4-(p-chlorophenyl)-1H-imidazol-2-yl)-4'-phenyl-1'H-pyrazole-3'-carboxamide

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