2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

Base Information

Chemical Name:2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one
CAS No.:112249-44-2
Molecular Formula:C₂₆H₃₃N₃O₃
Molecular Weight:435.566
Hs Code.:

Synonyms:2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

There total 8 articles about 2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 112249-72-6
2-(3-bromopropyl)-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

: 112249-44-2
2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1248/cpb.39.2896

Reference yield:

: 6240-79-5
5,6,7,8-Tetrahydro-3-nitro-2-naphthol

: 112249-44-2
2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98.2 percent / K₂CO₃ / dimethylformamide / 8 h / Ambient temperature

2: 81.1 percent / H₂ / 5percent Pd/C / ethanol

3: 90 percent / NEt₃ / dimethylformamide / 80 °C

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896

Reference yield:

: 32337-86-3
1-bromo-5,6,7,8-tetrahydronaphthalen-2-ol

: 112249-44-2
2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-6,7,8,9-tetrahydro-4H-naphtho[2,3-b][1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 55.7 percent / fuming HNO₃, AcOH / 1 h / Ambient temperature

2: 95.8 percent / H₂ / 5percent Pd/C / methanol; tetrahydrofuran

3: NaHCO₃ / ethyl acetate; H₂O / 0.5 h / 0 °C

4: 72 percent / K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

5: 90 percent / NEt₃ / dimethylformamide / 80 °C

With hydrogen; nitric acid; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896