(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

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Chemical Name:(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid
CAS No.:831235-51-9
Molecular Formula:C₄₁H₅₃NO₅SSi
Molecular Weight:700.027
Hs Code.:

(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

Synonyms:(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

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Chemical Property of (S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

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Technology Process of (S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

There total 6 articles about (S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4875-10-9
o-nitrothiophenol

: 831235-46-2
(S)-2-[(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-5-((R)-1-methanesulfonyloxymethyl-2-methyl-propyl)-7-methyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl]-propionic acid

: 831235-51-9
(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 55 ℃; for 8h;
DOI:10.1021/jo048456c

Reference yield:

: 831235-45-1
Methanesulfonic acid (R)-2-[(1R,4aS,5R,7S,8aR)-7-(tert-butyl-diphenyl-silanyloxy)-3-methyl-5-((S)-1-methyl-2-oxo-ethyl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-3-methyl-butyl ester

: 831235-51-9
(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄*H₂O / 2-methyl-propan-2-ol; acetonitrile / 2 h / 20 °C

2: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 55 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jo048456c

Reference yield:

: 831235-44-0
Methanesulfonic acid (R)-2-[(1R,4aS,5R,7S,8aR)-7-(tert-butyl-diphenyl-silanyloxy)-5-((S)-2-hydroxy-1-methyl-ethyl)-3-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl]-3-methyl-butyl ester

: 831235-51-9
(S)-2-{(1R,3S,4aR,5R,8aS)-3-(tert-Butyl-diphenyl-silanyloxy)-7-methyl-5-[(R)-2-methyl-1-(2-nitro-phenylsulfanylmethyl)-propyl]-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 3 h / -78 °C

2: 97 percent / 2-methyl-2-butene; aq. NaClO₂; NaH₂PO₄*H₂O / 2-methyl-propan-2-ol; acetonitrile / 2 h / 20 °C

3: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 8 h / 55 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 1: Swern oxidation;
DOI:10.1021/jo048456c