2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid

Base Information

• Chemical Name: 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid
• CAS No.: 267890-23-3
• Molecular Formula: C₂₃H₂₁N₃O₄
• Molecular Weight: 403.437
• Mol file: 267890-23-3.mol

Synonyms:2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid

Chemical Property of 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid

There total 2 articles about 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid (267890-09-5) + 2,4-dimethoxy-5-iodopyrimidine (52522-99-3) → 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid (267890-23-3)

Guidance literature:

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid; With sodium; In methanol; for 0.0833333h;

2,4-dimethoxy-5-iodopyrimidine; With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 24h; Further stages.;

DOI:10.1039/a908682j

Reference yield:

Methyl 2-(N-benzyl-N-prop-2'-ynyl)aminobenzoate (267890-08-4) → 2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid (267890-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 83.12 percent / potassium hydroxide; water / methanol / 24 h / 20 °C

2.1: Na / methanol / 0.08 h

2.2: 64 percent / Et₃N / (PPh₃)2PdCl₂; CuI / acetonitrile; dimethylformamide / 24 h / 20 °C

With potassium hydroxide; water; sodium; In methanol; 1.1: Hydrolysis / 2.1: Salt formation / 2.2: Substitution;

DOI:10.1039/a908682j

Reference yield: 73.0%

2-{N-Benzyl-N-[3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl]amino}benzoic acid (267890-23-3) → (Z)-1,2,3,5-Tetrahydro-1-benzyl-3-[(2,4-dimethoxypyrymidin-5-yl)methylidene]-4,1-benzoxazepin-5-one

Guidance literature:

With copper(l) iodide; triethylamine; In acetonitrile; at 80 ℃; for 16h;

DOI:10.1039/a908682j

upstream raw materials:

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid

2,4-dimethoxy-5-iodopyrimidine

Methyl 2-(N-benzyl-N-prop-2'-ynyl)aminobenzoate