diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate

Base Information

• Chemical Name: diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate
• CAS No.: 1070895-14-5
• Molecular Formula: C₂₃H₃₇NO₆Si
• Molecular Weight: 451.635
• Mol file: 1070895-14-5.mol

Synonyms:diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate

Chemical Property of diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate

There total 1 articles about diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-acetylaminomalonic acid diethyl ester (1068-90-2) + 2-(4’-t-butyldimethylsilyloxyphenyl)-1-iodoethane (185063-17-6) → diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate (1070895-14-5)

Guidance literature:

2-acetylaminomalonic acid diethyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h;

2-(4’-t-butyldimethylsilyloxyphenyl)-1-iodoethane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2008.07.003

Reference yield: 69.0%

diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate (1070895-14-5) → 2-amino-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)-1,3-propanediol (1130205-77-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.bmc.2008.07.003

Reference yield:

1-Bromoheptane (629-04-9) + diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate (1070895-14-5) → 2-acetylamino-2-(2-[4-(heptyloxy)phenyl]ethyl)malonic acid diethyl ester (162358-41-0)

Guidance literature:

diethyl 2-(acetylamino)-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)malonate; With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

1-Bromoheptane; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1039/c6ob00556j

upstream raw materials:

2-acetylaminomalonic acid diethyl ester

2-(4’-t-butyldimethylsilyloxyphenyl)-1-iodoethane

Downstream raw materials:

2-amino-2-(4-{[1-(tert-butyl)-1,1-dimethylsilyl]oxy}phenethyl)-1,3-propanediol

2-acetylamino-2-(2-[4-(heptyloxy)phenyl]ethyl)malonic acid diethyl ester