2-(4-heptyloxyphenyl)-5-cyanopyridine

Base Information

• Chemical Name: 2-(4-heptyloxyphenyl)-5-cyanopyridine
• CAS No.: 107487-92-3
• Molecular Formula: C₁₉H₂₂N₂O
• Molecular Weight: 294.396
• Mol file: 107487-92-3.mol

Synonyms:2-(4-heptyloxyphenyl)-5-cyanopyridine

Chemical Property of 2-(4-heptyloxyphenyl)-5-cyanopyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(4-heptyloxyphenyl)-5-cyanopyridine

There total 6 articles about 2-(4-heptyloxyphenyl)-5-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

→ 2-(4-heptyloxyphenyl)-5-cyanopyridine (107487-92-3)

Guidance literature:

Reference yield: 56.0%

2-Chloro-6-(4-heptyloxy-phenyl)-nicotinonitrile (107488-15-3) → 2-(4-heptyloxyphenyl)-5-cyanopyridine (107487-92-3)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In N,N-dimethyl-formamide; under 3800 Torr; Ambient temperature;

Reference yield:

4'-heptyloxyacetophenone (37062-61-6) → 2-(4-heptyloxyphenyl)-5-cyanopyridine (107487-92-3)

Guidance literature:

Multi-step reaction with 4 steps

1: Na wire / dioxane / 8 h / Ambient temperature

2: piperidine / acetic acid; H₂O / 1.)r.t., 8 h 2.)reflux, 16 h

3: 73 percent / PhPOCl₂ / 3 h / 140 - 160 °C

4: 56 percent / H₂/Et₃N / 10percent Pd/C / dimethylformamide / 3800 Torr / Ambient temperature

With piperidine; P,P-dichlorophenylphosphine oxide; hydrogen; sodium; triethylamine; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

2-Chloro-6-(4-heptyloxy-phenyl)-nicotinonitrile

4'-heptyloxyacetophenone

sodium 1-(4-heptylhydroxyphenyl)-3-on-1-propen-1-olate

6-(4-Heptyloxy-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile